Do the changes in the serum levels of IL-2, IL-4, TNFα, and IL-6 reflect the inflammatory activity in the patients with post-ERCP pancreatitis?

Kilciler, Guldem; Musabak, Ugur; Bagci, Sait; Yesilova, Zeki; Tuzun, Ahmet; UYGUN, Ahmet; Gulsen, Mustafa; Oren, Sema; Oktenli, Cagatay; Karaeren, Necmettin

doi:10.1155/2008/481560

Do the changes in the serum levels of IL-2, IL-4, TNFα, and IL-6 reflect the inflammatory activity in the patients with post-ERCP pancreatitis?

Kilciler G., Musabak U., Bagci S., Yesilova Z., Tuzun A., UYGUN A., ...Daha Fazla

Clinical and Developmental Immunology, cilt.2008, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 2008
Basım Tarihi: 2008
Doi Numarası: 10.1155/2008/481560
Dergi Adı: Clinical and Developmental Immunology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background. Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography (ERCP) procedure and there are some reports showing cytokine changes in ERCP-induced pancreatits. Goals. To investigate the association between early changes (within 24 hours) in the serum interleukin (IL)-2, IL-4, tumor necrosis factor (TNF) α, and IL-6 levels and the development of post-ERCP pancreatitis. Study. Forty five consecutive patients who underwent therapeutic ERCP and 10 patients with acute pancreatitis without ERCP were enrolled to the study. Serum concentrations of IL-2, IL-4, TNF α, and IL-6 were determined immediately before, 12 hours and 24 hours after ERCP. Results. Seven of the 45 patients (15.5%) developed post-ERCP pancreatitis. The levels of IL-4 at 24 hours after ERCP were significantly lower in the patients with post-ERCP pancreatitis than in those without pancreatitis, while TNF α levels at 12 hours after ERCP were higher in the complicated group than those of the uncomplicated group. The ratios of TNF α /IL-4 at 12 and 24 hours after ERCP were found significantly higher in the patients with post-ERCP pancreatitis than in those without pancreatitis. IL-6 in the complicated patients was found significantly increased at 24 hours after ERCP. Conclusions. The enhancement of serum TNF α and IL-6 levels in the patients with ERCP-induced pancreatitis reflects the inflammatory activity. Additionally, these cytokines together with IL-4 can be used in clinical laboratory monitoring of ERCP. Copyright © 2008 Guldem Kilciler et al.