Gallbladder Involvement of Diffuse Large B-Cell Lymphoma with18F-FDG PET/CT 18F-FDG PET/CT Görüntüleme ile Diffüz Büyük B Hücreli Lenfomanın Safra Kesesi Tutulumu
Turkish Journal of Hematology, cilt.39, sa.2, ss.140-141, 2022 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Teknik Not
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.4274/tjh.galenos.2020.2020.0693
- Dergi Adı: Turkish Journal of Hematology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.140-141
- Anahtar Kelimeler: F-18-FDG PET/CT, Gallbladder, Non-Hodgkin's lymphoma
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
18F-Fluoro-2-deoxy-glucose positron emission tomography/ computed tomography (18F-FDG PET/CT) is widely used in staging, restaging, and evaluation of treatment response in patients with lymphoma. In this case report, a 59-year-old woman diagnosed with diffuse large B-cell lymphoma (DLBCL) with gallbladder involvement is presented. Immunohistochemical analysis showed strongly positive CD79a, bcl-6, MUM1, bcl-2, and CD43; weakly positive CD20 and CD5 staining; negative c-myc; and Ki-67 of 85%. Interim18F-FDG PET/CT showed involvement of multiple lymph nodes with high radiopharmaceutical uptake in supra-and infradiaphragmatic lymphatic stations (Figure 1). On the other hand, increased18F-FDG uptake was observed in newly developed metastatic nodes in addition to previous lesions in the supra/infradiaphragmatic regions on posttreatment PET/CT. Additionally, focal18F-FDG uptake (dashed arrows) in the upper outer quadrant of the right breast and unexpected gallbladder (GB) wall involvement (arrows) were observed (Figure 2).18F-FDG PET/CT is a diagnostic method for detecting metastatic lesions in GB [1,2,3]. Although the involvement of the breasts and thyroid in non-Hodgkin’s lymphoma is frequently reported, involvement of the GB is extremely rare [4,5,6]. Al-Katib et al. [7] detected extranodal involvement of the GB in an 83-year-old male with intravascular large B-cell lymphoma. Bai et al. [8] reported increased18F-FDG uptake in the GB without luminal pathology in a 15-year-old girl with Hodgkin’s disease. In our case,18F-FDG PET/CT imaging revealed DLBCL-related involvement in the GB. PET/CT is a useful tool for demonstrating unexpected organ involvements, such as in the GB.