Low vitamin D3 levels may be associated with herpes zoster reactivation
Przeglad Dermatologiczny, cilt.111, sa.3, ss.186-190, 2024 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 111 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.5114/dr.2024.144651
- Dergi Adı: Przeglad Dermatologiczny
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.186-190
- Anahtar Kelimeler: Herpes zoster, vitamin D, Varicella zoster virus
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Vitamin D affects the secretion of antimicrobial peptides associated with toll-like receptor (TLR), which have antiviral effects. Objective: It has been suggested that vitamin D may affect the susceptibility of the host to varicella zoster virus (VZV) infection and the clinical course of herpes zoster. Material and methods: In this study, 101 patients who were diagnosed with herpes zoster at the dermatology outpatient clinic and had a vitamin D result at the time of diagnosis and a control group of 100 healthy people were included. Results were analyzed statistically. Results: The 25-OH vitamin D levels of the patients ranged from 2.37 to 32.98 µg/l and the mean value was 14.25 ±7.20 µg/l. In the control group, 25-OH vitamin D levels ranged between 10.3 and 44.25 µg/l, and the mean value was 24.9 ±6.24 µg/l. 25-OH vitamin D levels in the patient group were significantly lower than the levels in the control group (p < 0.001). Conclusions: This study revealed that 25-OH vitamin D levels were significantly lower in patients with herpes zoster compared to the control group. 25-OH vitamin D deficiency may increase the risk of VZV reactivation and vitamin D supplementation may alleviate the course of the disease in vitamin D-deficient patients with herpes zoster.