Association of endocrine autoantibodies (anti-TPO, anti-GAD, anti-insulin) with histopathological severity in pediatric Celiac disease: a retrospective cohort study
BMC Pediatrics, cilt.26, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1186/s12887-025-06471-1
- Dergi Adı: BMC Pediatrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: Autoimmune thyroid disease, Celiac disease, Marsh classification, Type 1 diabetes mellitus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion, characterized by the development of specific autoantibodies. An increased incidence of type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease (ATD) has been reported in patients with CD. However, there is a gap in the literature regarding the association between the severity of CD and the levels of these autoantibodies. This study aimed to evaluate the relationship between the severity of CD and autoantibody levels associated with T1DM and ATD. Methods: Patients diagnosed with CD between 2010 and 2023 and followed for at least two years were included, provided that endocrine autoantibody levels were available. Patients were evaluated based on their demographic, clinical, biochemical, and pathological data. Results: A total of 248 patients were analyzed, with a median age of 11 years (Range: 3–18); 159 (64.1%) were female. Endocrine autoantibodies were found to be positive in 51 patients (20.6%). All patients with positive autoantibodies were aged 10 years or older (p < 0.001). Total villous atrophy was observed in 94 patients (37.9%) and 94 patients (37.9%) had findings consistent with Marsh 3 C. In multivariate analysis, the presence of endocrine autoantibodies emerged as the only independent factor associated with an increased Marsh grade (p < 0.001). Conclusion: Our study demonstrated that the presence of autoantibodies associated with T1DM and ATD was correlated with more severe histopathological findings in patients with CD. There is a need for prospective studies investigating the role of these autoantibodies in predicting the prognosis of CD.