Prospective randomized trial of oxytocin administration for active management of the third stage of labor

Oguz Orhan E., DİLBAZ B., Aksakal S. E., Altinbas S., ERKAYA S.

International Journal of Gynecology and Obstetrics, cilt.127, sa.2, ss.175-179, 2014 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.ijgo.2014.05.022
  • Dergi Adı: International Journal of Gynecology and Obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.175-179
  • Anahtar Kelimeler: Active management of third stage of labor, Labor augmentation, Oxytocin, Postpartum hemorrhage
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: To determine the most efficient route and timing of oxytocin administration for active management of the third stage of labor. Methods: A prospective randomized study was done at one center in Ankara, Turkey, between January and October 2010.Women with a singleton pregnancy (>37 weeks) who had a live vaginal birth were randomly allocated to four groups: iv-A (intravenous oxytocin after delivery of the fetus), iv-B (when anterior shoulder seen), im-A (intramuscular oxytocin after delivery), and im-B (when anterior shoulder seen). Postpartum blood loss within the first hour, hemoglobin, hematocrit, and duration of the third stage were compared. Results: A total of 600 eligiblewomen were recruited; 150were assigned to each group. Postpartumblood loss, prepartum and postpartum hemoglobin and hematocrit, and need for additional uterotonics were similar among groups (P > 0.05). The duration of the third stage of labor and changes in hemoglobin and hematocrit were significantly reduced in group iv-B (P < 0.05). Among women not exposed to oxytocin before delivery, postpartum blood losswas significantly lower in group iv-B (P= 0.019). Labor augmentationwas related to significantly increased postpartumblood loss in all groups except iv-A. Conclusion: Although postpartum blood loss was similar in all groups, early intravenous administration seemed to have beneficial effects. ClinicalTrials.gov: NCT01954186.