Ventricular functions in patients with graves' ophthalmopathy
Turkiye Klinikleri Cardiovascular Sciences, cilt.22, sa.2, ss.226-232, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 2
- Basım Tarihi: 2010
- Dergi Adı: Turkiye Klinikleri Cardiovascular Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.226-232
- Anahtar Kelimeler: Graves' ophthalmopathy, Tissue doppler echocardiography, Ventricular function
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Graves' orbitopathy (GO) is an inflammatory syndrome that affects orbital tissues in ∼50% of patients with Graves' disease. Antibodies against TSH receptors in GO patients were shown to lead to heart failure along with GO, affecting both orbital tissues and cardiac muscle. However, there are no studies which investigated cardiac functions in GO patients. In the present study we aimed to investigate the cardiac functions in GO patients with conventional and tissue Doppler imaging methods. Material and Methods: Fourty seven GO patients and 27 healthy individuals as a control group were included in our study. Left and right ventricular functions were assessed using echocardiography including two-dimensional, M-mode, and conventional Doppler as well as pulsed wave tissue Doppler imaging. Results: Left and right ventricle systolic and diastolic diameters and ejection fraction showed no difference in patients with GO and controls. Tissue Doppler analysis showed that right and left ventricle annular systolic velocities were similar between GO patients and control group. Diastolic function parameters also showed no significant difference between the patient group and controls. There were no correlation between the echocardiographically derived systolic and diastolic function parameters and TSH receptor antibody (TSHRAb) levels. Conclusion: Although there are some clues about the involvement of cardiac tissue in GO we showed that cardiac functions are preserved in GO and TSHRAb levels were not associated with any of the systolic and diastolic function parameters of the left and right ventricle. Copyright © 2010 by Türkiye Klinikleri.