Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores: A retrospective study
Wiener Klinische Wochenschrift, cilt.132, sa.7-8, ss.182-187, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 132 Sayı: 7-8
- Basım Tarihi: 2020
- Doi Numarası: 10.1007/s00508-020-01618-9
- Dergi Adı: Wiener Klinische Wochenschrift
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, MLA - Modern Language Association Database, Veterinary Science Database
- Sayfa Sayıları: ss.182-187
- Anahtar Kelimeler: Albumin, C-reactive protein, Presepsin, Sepsis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To investigate the prognostic value of the presepsin:albumin ratio and C‑reactive protein:albumin ratio in patients with sepsis in the intensive care unit (ICU). Methods: A total of 228 (129 males and 99 females) patients with newly diagnosed sepsis were included in the study. The relationship between the C‑reactive protein:albumin ratio, presepsin:albumin ratio, clinicopathologic parameters, and overall survival were investigated. The associations between C‑reactive protein:albumin ratio and presepsin:albumin ratio were evaluated alongside other inflammation-based prognostic scores such as quick Sepsis Related Organ Failure Assessment (qSOFA). Results: The presepsin:albumin ratio was significantly higher in non-survivors (p < 0.01). Patients with a high presepsin:albumin ratio had worse overall survival compared with patients with high C‑reactive protein:albumin ratio levels (p < 0.001). Conclusion: Presepsin and presepsin:albumin ratio are markers of adverse prognosis in patients with sepsis and are superior to C‑reactive protein and C‑reactive protein:albumin ratio for this purpose. Presepsin:albumin ratio may be a novel marker of poor prognosis in patients with sepsis in intensive care units.