Unusual presentation: concomitant segmental vitiligo, segmental morphea, and lichen striatus
Irish Journal of Medical Science, cilt.194, sa.6, ss.2179-2182, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 194 Sayı: 6
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/s11845-025-04033-z
- Dergi Adı: Irish Journal of Medical Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.2179-2182
- Anahtar Kelimeler: Autoimmune dermatoses, Blaschko lines, Genetic mosaicism, Lichen striatus, Segmental morphea, Segmental vitiligo
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Segmental vitiligo, segmental morphea, and lichen striatus are distinct dermatological conditions that may share pathogenic mechanisms involving genetic mosaicism and immune dysregulation. Their simultaneous occurrence is extremely rare and may offer insights into their shared etiology. Case presentation: A 24-year-old female presented with a 6-year history of progressive indurated and discolored skin lesions. Dermatological examination revealed dermatomal depigmented macules consistent with segmental vitiligo on the right trunk, a violaceous Blaschkoid macule compatible with lichen striatus on the right lateral trunk, and multiple sclerotic plaques on the left side, consistent with segmental morphea. Histopathological examination confirmed the diagnosis of all three entities: loss of melanocytes in vitiligo, dermal sclerosis in morphea, and epidermal spongiosis with lymphocytic infiltrates and melanophages in lichen striatus. Conclusion: To our knowledge, this is the first reported case presenting the concurrent manifestation of segmental vitiligo, segmental morphea, and lichen striatus in the same patient. The segmental and Blaschkoid distribution patterns support a common pathogenic basis likely rooted in genetic mosaicism triggered by an autoimmune mechanism. Recognition of this rare co-occurrence may help elucidate the shared immunopathological mechanisms underlying these conditions.