Growth hormone, growth hormone receptor and insulin-like growth factor serum levels in patients with obesity and food addiction
Ukrainian Biochemical Journal, cilt.93, sa.6, ss.70-75, 2021 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 93 Sayı: 6
- Basım Tarihi: 2021
- Doi Numarası: 10.15407/ubj93.06.070
- Dergi Adı: Ukrainian Biochemical Journal
- Derginin Tarandığı İndeksler: Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.70-75
- Anahtar Kelimeler: Food addiction, Growth hormone, Growth hormone receptor, Insulin-like growth factor 1, Obesity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Obesity is a public health problem that increasingly becomes widespread and causes various compli-cations. Food addiction is a hedonic eating behavior characterized by overconsumption of palatable foods (i.e., foods involve a high amount of salt, sugar and fat). Disturbances in the growth hormone signaling path-way were shown to be associated with increased food intake and adiposity. The study aimed to determine the growth hormone (GH), growth hormone receptor (GHR), insulin, and insulin-like growth factor 1 (IGF-1) serum levels in individuals with obesity and food addiction. The present study involved 30 adults with obesity (23 females and 7 males) and 10 healthy adults (5 females and 5 males). 18 obese adults were diagnosed with food addiction, whereas only 2 individuals with food addiction were in the control group. GH, GHR, IGF-1 and insulin values were analyzed with ELISA kits. It was revealed that the obese subjects had significantly lower serum IGF-1 levels compared to healthy individuals (144.55±22.69 ng/ml vs 338.70±61.90 ng/ml, P < 0.001)). No significant differences in the GH, GHR and insulin levels between obese and control groups were detected (P > 0.05). No significant differences between the group with food addiction and the group with-out food addiction in terms of gender, age, weight, BMI, GH, GHR, insulin and IGF-1 levels were observed. Our study demonstrates that normal IGF-1 levels may be protective for the development of obesity. The serum levels of GH, GHR, insulin, IGF-1 are not associated with food addiction and, therefore, can not be used as novel markers of food addiction.