Treatment Results of Multidrug-Resistant Tuberculosis Patients in the Aegean Region
Thoracic Research and Practice, cilt.24, sa.2, ss.103-108, 2023 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.5152/thoracrespract.2023.22087
- Dergi Adı: Thoracic Research and Practice
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.103-108
- Anahtar Kelimeler: Tuberculosis, treatment, mortality, multidrug-resistant tuberculosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: We aimed to evaluate 109 rifampicin-resistant or multidrug-resistant tuberculosis patients who are treated in Izmir Chest Diseases MDR Tuberculosis Centre. MATERIAL AND METHODS: The patient profile, side effects, treatment success, and mortality of rifampicin-resistant or multidrug-resistant tuberculosis patients who were followed up and treated in our hospital’s tuberculosis service between 2010 and 2018 were analyzed retrospectively. RESULTS: Of the rifampicin-resistant or multidrug-resistant tuberculosis patients, 83 (76.1%) were male and the mean age was 46.3 ± 16.3 years. Of the cases 13 (11.9%) had rifampicin resistance without isoniazid. Since 5 out of 109 patients diagnosed with multidrug-resistant tuberculosis emigrated to other countries, the treatment results of 104 patients were evaluated. As a result of the treatment, the cure was achieved in 81 (77.9%) patients and treatment was completed in 13 (12.5%). Treatment success was found as 90.4%. No patient experienced recurrence. The mortality rate was determined as 9.6%. The cure rate of patients treated with ≥6 drugs (90.9%) was statisti-cally significantly (P =.029) higher than the group treated with ≤5 drugs (71.8%). CONCLUSIONS: Multidrug-resistant tuberculosis treatment is a long-term, financially burdensome practice that may cause serious sideffects and complications, and it requires strict discipline. The fight against tuberculosis can be successful with tuberculosis control pro-grams that are pursued with determination.