Asymptomatic fatty liver in patients normal transaminase levels: Initially target organ damage in overweight Transamİnaz yükseklİǧİ olmayan olgularda asemptomatİk karacİǧer yaǧlanmasi: Kİlo fazlaliǧinda hedef organ hasari başlangici
Anatolian Journal of Clinical Investigation, cilt.6, sa.4, ss.211-215, 2012 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 4
- Basım Tarihi: 2012
- Dergi Adı: Anatolian Journal of Clinical Investigation
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.211-215
- Anahtar Kelimeler: Nonalcoholic fatty liver disease, Overweight, Target organ damage
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Although fatty liver mostly is an asymptomatic and reversible process, in some cases it can lead to advanced liver disease and related deaths. In addition, prevalence of these cases have increased in the recent years. In the presented study, the liver or target organ damage of patients with normal transaminase levels but asymptomatic fatty liver disease was investigated. 315 male patients were included in the study (240 of them had fatty liver disease). Among the patients with fatty liver disease detected via ultrasonographic investigation. The cases were divided into three groups; those with fatty liver and normal transaminase levels (AST and ALT ≤ 40 IU/L), those with normal transaminase levels and without fatty liver and those with elevated transaminase levels (AST and ALT > 40 IU/L) and fatty liver. The patients who had HBsAg, Anti-HCV or Anti-HIV, systematic disease, history of alcohol (>20gr/day) and drug abuse were excluded. The patients with normal transaminase levels and fatty liver demonstrated a significantly higher ALT level in comparison to the patients with normal transaminase levels and without fatty liver (P<0.005). The AST/ALT ratio was found to be decreased (<1) along with hepatosteatosis formation. Moreover, a statistically significant correlation was detected between fatty liver disease and ALT, BMI, WC, TG and FBG levels, respectively r=0.701, r=0.570, r=0.577, r=0.547 and r=0.268,(P<0.05). In subjects with overweight, hypertriglyceridemia and normal transaminase levels, the elevated ALT levels relative to the AST values can be recognized as a reliable sign of fatty liver and initially target organ damage. Thus it may be possible to prevent possible illnesses related to this phenomenon with protective measures taken at an early stage.