Development of multiple myeloma in the course of chronic lymphocytic leukemia: Case report Kronik lenfositik lösemi seyrinde multipl miyelom gelişimi: Olgu sunumu
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.18, sa.4, ss.238-241, 2008 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 4
- Basım Tarihi: 2008
- Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.238-241
- Anahtar Kelimeler: Chronic lymphocytic leukemia, Multiple myeloma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are chronic B cell malignancies originating from different phases of B cell development. They are rarely seen together. A 64 year-old male diagnosed with CLL was being followed up, bone marrow biopsy were performed after the devolopment of hyperglobulinemia and increased serum urea values. Bone marrow biopsy revealed an increase of 40% atypical plasma cell count and 35% lymphocyte count. Although no alkylating agent was used, additional development of MM clone to CLL is remarkable. This situation was seen very rarely in the literature. We aimed to present this case to be an instrument in the understanding of B cell oncogenesis in molecular level.