Investigation of Human Bocavirus in Patients Followed Up for Acute Respiratory Tract Infection in the Pediatric Intensive Care Unit Pediyatrik Yoğun Bakım Ünitesinde Akut Solunum Yolu Enfeksiyonu Nedeniyle Takip Edilen Hastalarda İnsan Bokavirüsünün Araştırılması
Cocuk Enfeksiyon Dergisi, cilt.20, sa.2, ss.120-126, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.5578/ced.20260214
- Dergi Adı: Cocuk Enfeksiyon Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), CINAHL, EMBASE, TR DİZİN (ULAKBİM), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.120-126
- Anahtar Kelimeler: acute respiratory tract infection, Human bocavirus, paediatric intensive care
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to investigate the clinical characteristics of pediatric patients diagnosed with acute respiratory infections in the Pediatric Intensive Care Unit at Bakırköy Dr. Sadi Konuk Training and Research Hospital, whose nasopharyngeal swab samples tested positive for human bocavirus (HBoV). The prevalence of HBoV as a solitary infection or in co-infection and its clinical distinctions were examined. Material and Methods: The study included 50 children who were monitored in the Pediatric Intensive Care Unit of Bakırköy Dr. Sadi Konuk Training and Research Hospital between 2015 and 2021 diagnosed with acute respiratory infections and were found to be positive for HBoV in nasopharyngeal swab samples. Demographic and clinical information for all patients was collected, and symptoms such as respiratory distress, cough, and fever were recorded. Nasopharyngeal swab samples were analyzed using a polymerase chain reaction panel that tested for 14 different viruses to determine the presence of HBoV and other viral agents. Patients with solitary HBoV infection and those with detected co-infections were compared to assess clinical progressions and laboratory findings. Statistical analyses were conducted using IBM SPSS Statistics 22 (IBM SPSS, Türkiye), with a significance level set at p< 0.05. Results: It was determined that 86% of the 50 patients included in the study were under the age of three. Rhinovirus was identified as the most common co-infecting agent. Patients in the co-infection group exhibited significantly longer durations of symptoms (p= 0.014), and the frequency of atelectasis was notably higher in the co-infection group (p= 0.009). In the group with sole HBoV infection, eosinophil levels were found to be significantly higher (p= 0.002). Conclusion: This study demonstrates that HBoV can appear both as a sole infection and in co-infection in children suffering from acute respiratory infections. No significant differences in clinical symptoms were observed between the groups. The duration of breastfeeding was found to be longer in the group with sole HBoV infection. Patients in the co-infec-tion group exhibited longer durations of symptoms. Patients with only HBoV infection had a higher absolute eosinophil count while a higher incidence of atelectasis was observed in the co-infection group. These findings suggest the need for further studies to confirm these observations.