Durability of antibody level after rabies immunization and comparison of gene expression with unvaccinated subjects
Southeast Asian Journal of Tropical Medicine and Public Health, cilt.52, sa.4, ss.557-571, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52 Sayı: 4
- Basım Tarihi: 2021
- Dergi Adı: Southeast Asian Journal of Tropical Medicine and Public Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.557-571
- Anahtar Kelimeler: antibody level, gene expression, immunization schedule, rabies, Turkey, vaccine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Immunization before and after exposure remain the most effective way to protect against rabies. A cross-sectional comparison of antibody level durability induced by a full (4-dose) or a 3-dose rabies vaccination was investigated and whether changes occurred in ERK1, ERK2, MEK1, and CXCL10 gene expression post-vaccination. Blood samples of adult subjects who received the full (n = 32) and 3-dose (n = 19) rabies vaccine at Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences Turkey, Istanbul, Turkey were taken 6-18 months post-vaccination for assay of antibody and expression levels of the above-mentioned genes. Antibody levels in about 10 % of subjects receiving both vaccination regimen decreased below protective level (>0.5 IU/ml) within 12 months post-vaccination, but there were no differences in expression levels of the four test genes in the two vaccinated groups compared to unvaccinated individuals (n = 30). In conclusion, subjects receiving both rabies vaccination regimens should be given a booster shot within one year to maintain an adequate prophylactic immune status.