Vitamin D receptor gene polymorphisms are not associated with alopecia areata
International Journal of Dermatology, cilt.46, sa.9, ss.927-929, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 9
- Basım Tarihi: 2007
- Doi Numarası: 10.1111/j.1365-4632.2007.03140.x
- Dergi Adı: International Journal of Dermatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.927-929
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background: It has been demonstrated that the vitamin D receptor (VDR) is strongly expressed in key structures of hair follicles, and a lack of VDR leads to alopecia. We investigated whether there was any association between VDR gene polymorphisms ( Bsm I, Apa I, and Taq I) and alopecia areata (AA). Methods: Thirty-two patients with AA and 27 healthy control subjects were genotyped using polymerase chain reaction and restriction fragment length polymorphism analysis. Results: In the patient group, the B and b allele frequencies were 53.1% and 46.9%, A and a allele frequencies were 70.3% and 29.7%, and T and t allele frequencies were 62.5% and 37.5%, respectively. In the control group, the corresponding values were 51.9% and 48.1%, 63.0% and 37.0%, and 77.8% and 22.2%, respectively. In the patient group, the BB , Bb , and bb genotype frequencies were 25.0%, 56.2%, and 18.8%, AA , Aa , and aa genotype frequencies were 43.8%, 53.1%, and 3.1%, and TT , Tt , and tt genotype frequencies were 37.5%, 50.0%, and 12.5%, respectively. In the control group, the corresponding values were 11.1%, 81.5%, and 7.4%, 29.6%, 66.7%, and 3.7%, and 63.0%, 29.6%, and 7.4%, respectively. None of the allele or genotype frequencies showed statistically significant differences between the patient and control groups. Conclusion: These findings suggest that there is no relationship between VDR gene polymorphisms and AA. © 2007 The International Society of Dermatology.