The relationship between serum uric acid levels and development of obesity in living kidney donors after donor nephrectomy
European Journal of Clinical Investigation, cilt.51, sa.6, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 6
- Basım Tarihi: 2021
- Doi Numarası: 10.1111/eci.13507
- Dergi Adı: European Journal of Clinical Investigation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Anahtar Kelimeler: kidney transplantation, living kidney donors, metabolic syndrome, obesity, serum uric acid
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Hyperuricaemia plays a role in the pathogenesis of obesity and related metabolic disorders. The aim of this study to investigate the relationship between pre-donation serum uric acid (SUA) level and obesity development after nephrectomy in living kidney donors. Methods: Living donors of kidney transplants between 1998 and 2019 were evaluated. Donors with less than 1 year of follow-up were excluded from the study. The participants were divided into two groups according to last control body mass index (BMI) (obese; ≥ 30 kg/m2 and nonobese; <30 kg/m2) and median baseline SUA level (<4.6 mg/dL and ≥4.6 mg/dL). Results: In the included 240 donors, the mean follow-up was 50 ± 44 (12-216) months. The mean age was 47 ± 11 (19-82) years, and 46.6% of donors were male. At last control, the percentage of obese donors had increased significantly compared to pre-donation time (22.5% vs 33.8%; P <.001) and last control obese donors had both higher baseline SUA (5.1 ± 1.4 vs 4.5 ± 1.2; P <.01) and BMI (30.7 ± 2.6 vs 24.8 ± 3.0; P <.001). Cox regression analysis showed that there is an independent relationship between the baseline SUA level and development of obesity (odds ratio: 1.30 [CI; 1.12-1.50]; P <.001). In Kaplan-Meier analysis, the development of obesity was significantly higher in kidney donors with high SUA level. Conclusion: Living kidney donors (LKD) have a tendency to obesity after nephrectomy. Preoperative serum uric acid level gives important information in LKDs that it could foresee the development of obesity after donation.