Association of Delayed Vitamin D Supplementation and Low Thyroxine Levels with Bronchopulmonary Dysplasia Severity in Preterm Infants Prematüre Bebeklerde D Vitamini Takviyesinin Gecikmesi ve Düşük Tiroid Hormon Seviyelerinin Bronkopulmoner Displazi Şiddetiyle İlişkisi
Guncel Pediatri, cilt.24, sa.2, ss.97-104, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/jcp.2026.90094
- Dergi Adı: Guncel Pediatri
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.97-104
- Anahtar Kelimeler: Bronchopulmonary dysplasia, prematurity, risk factors, vitamin D, free thyroxine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: The development of bronchopulmonary dysplasia (BPD) is multifactorial, and the extent to which individual risk factors influence its development may vary. The aim of this study is to analyse the risk factors for BPD and to determine preventive future approaches for them. Materials and Methods: This study was conducted on newborns with a gestational age ≤32 weeks. admitted to the neonatal intensive care unit, Antenatal, natal, and postnatal risk factors for premature infants were evaluated by collecting data from patient files using a retrospective cross-sectional descriptive study method. Results: According to the inclusion criteria, 539 patients were included in the study. BPD was detected in 172 patients (31.9%) at any stage (mild-moderate-severe). Low gestational age, low birth weight, delayed transition to enteral feeding, low free thyroxine levels, delayed initiation of vitamin D supplementation, erythrocyte transfusion and counts, and prolonged respiratory support durationwere found to be risk factors for BPD development (p<0.05). According to the results of the multivariate logistic regression analysis, the day of oxygen restriction [odds ratio (OR), 1.332; 95% confidence interval (CI) 1.064–1.667, p=0.012] and red blood cell transfusion (OR 41.865, 95% CI 1.337–1310.596, p=0.034) were found to be independent risk factors for BPD. Conclusion: In our study, oxygen support period and erythrocyte transfusion may independent risk factors for BPD development. Additionally, as a significant new finding, we determined that low free thyroxine levels and delayed initiation of vitamin D supplementation may be related to the severity of BPD.