The evaluation of ovarian reserve and menstrual irregularities in female patients treated with systemic isotretinoin Sistemik izotretinoin ile tedavi edilen kadın hastalarda over rezervinin ve menstrüel düzensizliklerin değerlendirilmesi
Turkderm Turkish Archives of Dermatology and Venereology, cilt.54, sa.3, ss.79-84, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.4274/turkderm.galenos.2020.37974
- Dergi Adı: Turkderm Turkish Archives of Dermatology and Venereology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.79-84
- Anahtar Kelimeler: AMH, isotretinoin, menstrual irregularities, ovarian reserve
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background and Design: Isotretinoin is a widely used retinoid for the treatment of many dermatological conditions notably in acne with many known side effects. This study aims to investigate the effects of isotretinoin on anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH) and total antral follicle count (TAFC) as the indicators of ovarian reserve (OR) and also aims to investigate the frequency of menstrual irregularities (MI). Materials and Methods: Ninety-two reproductive women were included in this prospective controlled study. Study group is consisted of 32 healthy control, 29 low-dose (0.4-0.6 mg/kg/day mean: 0.56±0.06) and 31 high-dose isotretinoin received patients (0.7-1.1 mg/kg/day mean: 0.94±0.11). AMH, FSH and TAFC were evaluated before and at 6th month of treatment in the treatment group, while AMH and FSH levels were evaluated in the control group. Results: Mean AMH level of treatment group at the 6th month of treatment was significantly lower than the level prior to treatment and that of the control group (p<0.001, p=0.013). Mean FSH level was increased, and TAFC level was decreased compared to pretreatment period (p=0,912, p=0,824). Seventeen patients (28.3%) had MI during treatment. Conclusion: Although decrease in antral follicle numbers and increase in FSH levels were not significant, significant decreases in AMH levels may indicate the negative effect of isotretinoin on OR.