Is screening for Cushing's syndrome before bariatric surgery necessary? Bariatrik cerrahi öncesi Cushing sendromu için tarama testi gerekli midir?
Pamukkale Medical Journal, cilt.13, sa.3, ss.529-533, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.31362/patd.694115
- Dergi Adı: Pamukkale Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.529-533
- Anahtar Kelimeler: bariatric surgery, Cushing's syndrome, dexamethasone suppression test, Obesity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: Recent studies have shown a higher prevalence of Cushing's syndrome in obese patients with type 2 diabetes, but its prevalence in overweight and obese populations is not clear. The aim of this study was to evaluate the need for screening tests for Cushing's syndrome in morbidly obese individuals before bariatric surgery. Materials and methods: Between January 2015 and December 2019, 300 patients with Body Mass Index (BMI) ≥35 kg/m2 that admitted to our endocrine outpatient clinic for evaluation before bariatric surgery were included in this study. Overnight low dose 1 mg dexamethasone suppression test was applied to all patients. Next day 8 am serum cortisol concentration less than 1.8 μg/dL was defined as normal suppression. Results: Three hundred patients undergoing bariatric surgery were screened for Cushing's syndrome. The mean±standard deviation age of the patients was 39.4±11.7 years and 236 (77.3%) were women. The mean BMI of the patients was 45.9±5.5 kg/m2 before bariatric surgery. Forty-seven (15.7%) patients in type 2 diabetes mellitus, 28 (9.3%) patients with hypertension and 3 (1%) patients who had achived euthyroidism after levothyroxine treatment. The mean one year BMI after bariatric surgery was 28±4.6 kg/m2. Serum cortisol concentration was <1.8 μg/dL after 1 mg overnight dexamethasone suppression test in all patients. Conclusion: The results of the evaluated data revealed that the routine screening of morbidly obese individuals for Cushing's syndrome before bariatric surgery is not necessary.