Preoperative predictors of pelvic and para-Aortic lymph node metastases in cervical cancer
Journal of Cancer Research and Therapeutics, cilt.15, sa.6, ss.1231-1234, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 6
- Basım Tarihi: 2019
- Doi Numarası: 10.4103/jcrt.jcrt_467_17
- Dergi Adı: Journal of Cancer Research and Therapeutics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1231-1234
- Anahtar Kelimeler: Cervical cancer, lymphovascular space invasion, para-aortic lymph node, pelvic lymph node
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: This study investigated potential preoperative predictors of pelvic lymph node (PLN) and para-Aortic LN (PaLN) involvement in cervical cancer (CC). Materials and Methods: This study retrospectively analyzed 283 patients diagnosed with early (stage IA1-IIA) CC who underwent retroperitoneal LN dissection between January 1992 and February 2015. Several risk factors that are believed to influence PLN and PaLN involvement in CC were analyzed as follows: Age >50 years, lymphovascular space invasion (LVSI), tumor size ≥2 cm, hemoglobin <12 g/dL, and nonsquamous cell histologic type. Results: LVSI (odds ratio [OR] = 11.3, 95% confidence interval [CI] = 5.2-24.3) and tumor size (OR = 3.2, 95% CI = 1.4-7.2) were independent predictors of PLN involvement. None of the factors predicted PaLN involvement in a regression analysis. However, all nine patients who had PaLN involvement also had PLN involvement. Conclusion: LVSI and tumor size independently increase the risk of PLN involvement.