Leptin in acute coronary syndromes: Has the time come for its use in risk stratification?
International Journal of Cardiology, cilt.130, sa.2, ss.264-265, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 130 Sayı: 2
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.ijcard.2007.07.007
- Dergi Adı: International Journal of Cardiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.264-265
- Anahtar Kelimeler: Leptin, Acute coronary syndromes, Thrombosis
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Leptin, a recently discovered obesity gene product, is primarily involved in the regulation of food intake and energy expenditure. Recent observations suggest that leptin has a much broader biological role other than regulation of body weight and energy metabolism. It has been shown that leptin increases sympathetic nerve activity, stimulates generation of reactive oxygen species, induces platelet aggregation and promotes arterial thrombosis, and is an independent risk factor for coronary heart disease. In this paper, we discussed the role of leptin in the pathogenesis of acute coronary syndromes and its usefulness as a biomarker for risk stratification in acute coronary syndromes. © 2007 Elsevier Ireland Ltd. All rights reserved.