The effect of the scolocidal agents on the liver and bile ducts Skolosidal maddelerin karaciger ve safra yollarina etkileri
Gulhane Medical Journal, cilt.42, sa.3, ss.269-275, 2000 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 3
- Basım Tarihi: 2000
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.269-275
- Anahtar Kelimeler: Sclerosing Cholangitis, Scolocidal Agents
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study the effect of the scolocidal agents, which are mostly preferred in the management of the hydatid disease of the liver, on the liver and bile ducts was investigated. For this purpose, after examining the liver function tests and serum alkaline phosphatase, the gallbladder was catheterized via laparotomy in 30 rabbits. The laboratory animals were divided into 6 groups, 5 in each as control group, absolute alcohol group, % 10 PVP-i group, % 5 NaCl group, % 10 NaCl group, % 20 NaCl group. After the common bile duct was clamped, the gallbladder was infused with 6 different scolocidal agents and we waited for 5 minutes in all animals. The laparotomy was completed after suturing the infusion site, and the animals were closely followed-up for 30 days. The blood samples were again obtained for the liver function tests and serum alkaline phophatase at the 30th day. The tissue specimens of the liver, bile ducts and gall-bladder were removed by sacrification. As a result; when the liver function tests and serum alkaline phosphatase levels after the infusion of scolocidal agents were compared with the levels before the infusion, there was no statistically significant difference. However, in the groups in which absolute alcohol and hypertonic sodium chloride solutions (10%, 20%) were used, congestion, balloning degeneration, periductal inflammation, focal necrosis in the parenchyma of the liver and bile ducts, proliferation, fibrosis, precirrhotic changes in the bile ducts and the stasis of the bile were observed clearly more than the other groups. The histopathological changes caused by the absolute alcohol and hypertonic sodium chloride solutions (10%, 20%) on the liver and the bile ducts may develop even in such a short time as one month. In conclusion, we suggest that absolute alcohol and hypertonic sodium chloride 10 - 20% solutions shouldn't be used in the hydatid disease of the liver with possible communication to the bile ducts.