Vitamin D receptor polymorphisms in immune thrombocytopenic purpura
Pediatrics International, cilt.59, sa.6, ss.682-685, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 6
- Basım Tarihi: 2017
- Doi Numarası: 10.1111/ped.13273
- Dergi Adı: Pediatrics International
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.682-685
- Anahtar Kelimeler: children, immune thrombocytopenic purpura, polymorphism, Vitamin D receptor
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Vitamin D receptor (VDR) polymorphisms have been studied in immune-mediated disorders, but not yet in immune thrombocytopenic purpura (ITP). We investigated whether VDR variants were associated with ITP in children. Methods: The study included 44 children with a diagnosis of ITP and 100 healthy controls. Five VDR polymorphisms (Cdx-2, FokI, BsmI, ApaI and TaqI) were genotyped and used to evaluate the association of VDR variants with ITP. Results: The distribution of the three Cdx-2 genotype groups (GG, GA, and AA) was significantly different between ITP patients and controls (P = 0.025); the homozygous GG genotype of Cdx-2 was overrepresented in ITP patients. The frequency of the A allele of Cdx-2 was significantly different between patients and controls (P = 0.01). The A allele of Cdx-2 was associated with a decreased risk of ITP (OR, 0.343; 95% CI: 0.150–0.782). No statistically significant difference was found between the ITP group and control group for Fok1, Bsm1, Apa1, and Taq1 polymorphisms (P > 0.5). Conclusion: There appears to be an interaction between the Cdx-2 variant of VDR and childhood immune thrombocytopenia.