Hormone levels in children receiving anteipileptic treatment Antiepileptik tedavi alan çocuklarda serum hormon düzeyleri
Cocuk Sagligi ve Hastaliklari Dergisi, cilt.46, sa.3, ss.182-186, 2003 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 3
- Basım Tarihi: 2003
- Dergi Adı: Cocuk Sagligi ve Hastaliklari Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.182-186
- Anahtar Kelimeler: Antiepileptics, Sex hormones, Thyroid hormones
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
It has been demonstrated that epileptic patients receiving antiepileptics can show changes in serum hormone levels. We measured the levels of sex and thyroid hormones in 67 patients with epilepsy receiving valproic acid (VPA), carbamazepine (CBZ), and VPA+CBZ and in 25 healthy age-matched controls. In the patients receiving CBZ, levels of free thyroxine were significantly lower than in the control group, with sex hormone-binding globulin significantly higher. The endocrine effects of antiepileptic drugs should be considered when starting antiepileptic drug therapy and should be monitored closely. Indications:40 unspecified patients with epilepsy. Patients:67 patients. TypeofStudy:A study investigating the hormone levels of epileptic children receiving antiepileptic treatment including Tegretol. DosageDuration:Dosage and duration not stated. Results:In patients receiving Tegretol, levels of free thyroxine were significantly lower than in the control group, with significantly higher sex hormone-binding globulin. AdverseEffects:No adverse events were mentioned. AuthorsConclusions:The endocrine effects of antiepileptic drugs should be considered when starting antiepileptic drug therapy and should be monitored closely. FreeText:Tests: Levels of thyroid and sex hormones, including free thyroxin blood level, sex hormone-binding globulin level.