Serum interleukin-35 and pentraxin-3 levels in patients with mild acute pancreatitis
Przeglad Gastroenterologiczny, cilt.14, sa.1, ss.48-54, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.5114/pg.2019.83425
- Dergi Adı: Przeglad Gastroenterologiczny
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.48-54
- Anahtar Kelimeler: mild acute pancreatitis, interleukin-35, pentraxin-3
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Interleukin-35 (IL-35) is a newly defined potent anti-inflammatory cytokine that is predominantly produced by regulatory T cells, and pentraxin-3 belongs to the acute-phase proteins. Aim: To measure the serum IL-35 and pentraxin-3 levels in the early phase of mild acute pancreatitis (AP). Material and methods: Eighty-three patients with mild AP and 30 healthy controls were included in the study. The serum levels of IL-35 and pentraxin-3 were measured by enzyme-linked immunosorbent assay upon admission and at the 48 th hour after diagnosis. Results: The mean value of serum IL-35 levels in patients with mild acute pancreatitis at admission was 5.91 ng/ml (4.21–7.90) and was significantly lower than those in healthy controls (25.53 ng/ml (12.79–54.73, p < 0.001)) and 48-hour value were (6.79 ng/ml (4.42–9.62) (p = 0.015)). The mean value of serum pentraxin-3 levels in patients at the time of admission was 6.75 ng/ml (4.42–9.62) and there was no significant difference from healthy controls, at 7.64 ng/ml (6.58–8.62, p > 0.05). Also there was no significant difference between the mean value at admission and the mean value at 48-hour, 6.75 ng/ml (4.74–9.06, p > 0.05). Conclusions: Interleukin-35 can be used in diagnosis and follow-up in patients with mild AP.