Expression of voltage gated potassium channel ether à go-go in pituitary adenomas of patients with acromegaly: A preliminary study
Neuroendocrinology Letters, cilt.36, sa.2, ss.165-170, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 2
- Basım Tarihi: 2015
- Dergi Adı: Neuroendocrinology Letters
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.165-170
- Anahtar Kelimeler: Eag1, acromegaly, pituitary, Ki-67, cavernous sinus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: To determine immunohistochemical expression of Eagl in pituitary adenomas of patients with acromegaly and to assess the correlation between Eagl expression with cavernous sinus invasion, tumoral Ki-67 labeling index (LI), age and gender of the patients. METHODS: The paraffin embedded pituitary adenoma tissue sections of 28 patients with acromegaly who were diagnosed as monohormonal growth hormone (GH) secreting adenomas were immunostained for Eagl using the avidin-biotin-peroxidase complex method. Eagl immunoreactivity was scored according to the extensity of the cytoplasm and cell membrane immunoreactivity for Eagl (score 1 = <10%, score 2 = 10-25%, score 3 = 25-50% and score 4 = >50% of the adenoma cells showed immunoreactivity for Eagl, respectively). RESULTS: Overall, GH secreting pituitary adenomas displayed diverse levels of Eagl immunoreactivity, however, 64% of the adenomas displayed a strong Eagl immunoreactivity (score 3 and 4). Five of the tumors displayed Eagl immunoreactivity score 1, 5 displayed score 2, 10 displayed score 3 and 8 displayed score 4, respectively. No correlation was found between Eagl immunoreactivity with cavernous sinus invasion, Ki-67 LI, age and gender of the patients. CONCLUSIONS: Our results suggest Eagl is strongly expressed in the majority of GH secreting pituitary adenomas. However, we could not find any correlation between immunoreactivity of Eagl with cavernous sinus invasion, Ki-67 LI, age and gender of the patients. Further studies with larger sample sizes are required to demonstrate the role of Eagl on tumorigenesis, angiogenesis, invasion and response to the treatment in GH secreting pituitary adenomas.