The efficacy of pretreatment and after treatment 18F-FDG PET/CT metabolic parameters in patients with locally advanced squamous cell cervical cancer
Nuclear Medicine Communications, cilt.40, sa.3, ss.219-227, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.1097/mnm.0000000000000969
- Dergi Adı: Nuclear Medicine Communications
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.219-227
- Anahtar Kelimeler: cervical cancer, 18F-FDG PET/CT, maximum standardized uptake value, metabolic tumor volume, tumor lesion glycolysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives Cervical cancer is one of the main causes of cancer death worldwide. Fluorine-18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (PET/CT) has been playing an increasingly important role in staging and monitoring treatment response in the disease. In the current study, we investigated metabolic 18F-FDG PET/CT parameters among patients with locally advanced squamous cell cervical cancer treated with concurrent chemoradiotherapy for predicting disease-free survival (DFS). Patients and methods Forty-four patients with biopsy-proven locally advanced squamous cell cervical cancer were included in the study. Pretreatment and after treatment 18F-FDG PET/CT metabolic parameters [metabolic tumor volume, tumor lesion glycolysis, maximum standard uptake value (SUV max)] for the primary tumor area and/or pelvic/para-aortic lymph nodes and also accompanying distant metastases were analyzed. Treatment response was divided into four groups according to a post-treatment 18F-FDG PET/CT scan. Results For all patients, the 3-year DFS was 79%. Pretreatment primary tumor SUV max and tumor lesion glycolysis, pelvic lymph node SUV max, and pretreatment para-aortic lymph node SUV max were significant prognostic factors for DFS with different cut-off values. In contrast, for metabolic tumor volume-T1, there was no statistical significance for DFS. Conclusion 18F-FDG PET/CT cut-off values may help clinicians with their treatment planning and follow-up in locally advanced squamous cell cervical cancer patients.