Mining Database for The Clinical Significance, Prognostic Value and Expression of Mir-4746 In Hepatocellular Carcinoma Hepatosellüler Karsinomda Mir-4746’nın Klinik Önemi, Kestirim Değeri ve İfadesi İçin Veri Tabanı Madenciliği
Sakarya Medical Journal, cilt.13, sa.2, ss.216-222, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.31832/smj.1187165
- Dergi Adı: Sakarya Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.216-222
- Anahtar Kelimeler: bioinformatics, hepatocellular carcinoma, miR-4746, miRNA, prognosis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction MicroRNAs (miRNAs) are key regulators in the progression and development of hepatocellular carcinoma (HCC). In recent study the miR-4746 was found to be overexpressed in HCC, however, differential expression pattern and clinicopathological significance of miR-4746 in HCC remains unclear. In current study we aimed to evaluate expression profile, clinicopathological role and prognostic value of miR-4746 by using computational approaches. Materials and Methods The expression profile of miR-4746 in various human cancers was determined using the dbDEMC database. Also, we used ENCORI/Starbase v2 and UALCAN databases to analyze miR-4746 expression level in HCC. Moreover, we investigated clinicopathological function of miR-4746 by using UALCAN database. Finally, survival analysis was performed to determine prognostic significance of miR-4746 in HCC by Kaplan-Meier plotter and ENCORI/Starbase v2 databases. Results The miR-4746 had differential expression patterns in various human cancers and was significantly upregulated in HCC tissues compared with normal samples. Clinicopathological analysis revealed that, miR-4746 was differentially expressed in different clinical parameters including cancer stage, tumor grade, nodal metastasis status, TP53 mutation status, and patient’s age. In addition, high expression of miR-4746 was significantly correlated with poor prognosis in HCC. Conclusion Our findings indicated that miR-4746 might be as an oncogenic miRNA which were correlated with poor prognosis and worse clinicopathological outcomes. Furthermore, miR-4746 might have an important role in tumorigenesis of HCC and it might serve as potential prognostic biomarker.