The impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine
Central-European Journal of Immunology, cilt.37, sa.4, ss.303-306, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.5114/ceji.2012.32715
- Dergi Adı: Central-European Journal of Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.303-306
- Anahtar Kelimeler: Toll-like receptor, dexamethasone, newborn, intestine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The gastrointestinal system constitutes an important part of immune system in newborns. Toll-like receptors (TLRs) are pattern recognition molecules that initiate innate immune responses in newborn gut. The aim of the study was to investigate the responsiveness of intestinal Toll-like receptors 2 (TLR-2), TLR-4 and TLR-9 levels to postnatal steroid therapy. Material and methods: Rats were randomly assigned to three experimental groups. Group I (control at day 0) (n = 9), group II (control at day 10) (n = 9): oral distilled water, group III (study group) (n = 9): oral dexamethasone (0.5 mg/kg/day). After 10 days, the ileojejunal segment was removed for biochemical analyses of TLR-2, TLR-4 and TLR-9. Results: There was no statistically significant difference between groups for TLR-2 and TLR-4 levels. There was a significant difference between groups for TLR-9 levels. There were no significant difference between group I and III and both groups were significantly higher than group II for TLR-9 levels. Conclusions: Postnatal steroid treatment may reduce TLR-4 level via increasing the level of TLR-9. Thus, it may lead to limited beneficial and protective effect against necrotizing enterocolitis which is a deleterious disease of the newborn gastrointestinal tract.