Treatment of hypertriglyceridemia-induced acute pancreatitis with insulin
Przeglad Gastroenterologiczny, cilt.10, sa.1, ss.18-22, 2015 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.5114/pg.2014.45412
- Dergi Adı: Przeglad Gastroenterologiczny
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.18-22
- Anahtar Kelimeler: acute pancreatitis, hypertriglyceridemia, hyperlipidaemia, insulin
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Hypertriglyceridaemia (HT)-induced pancreatitis rarely occurs unless triglyceride levels exceed 1000 mg/dl. Hypertriglyceridaemia over 1,000 mg/dl can provoke acute pancreatitis (AP) and its persistence can worsen the clinical outcome. In contrast, a rapid decrease in triglyceride level is beneficial. Insulin-stimulated lipoprotein lipase is known to decrease serum triglyceride levels. However, their efficacy in HT-induced AP is not well documented. Aim: To present 12 cases of AP successfully treated by insulin administration. Material and methods: Three hundred and forty-three cases of AP were diagnosed at our clinic between 2005 and 2012. Twelve (3.5%) of these cases were HT-induced AP. Twelve patients who suffered HT-induced AP are reported. Initial blood triglyceride levels were above 1000 mg/dl. Besides the usual treatment of AP, insulin was administered intravenously in continuous infusion. The patients' medical records were retrospectively evaluated in this study. Results: Serum triglyceride levels decreased to < 500 mg/dl within 2-3 days. No complications of treatment were seen and good clinical outcome was observed. Conclusions: Our results are compatible with the literature. Insulin may be used safely and effectively in HT-induced AP therapy. Administration of insulin is efficient when used to reduce triglyceride levels in patients with HT-induced AP.