Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs
Acta Cirurgica Brasileira, cilt.29, sa.1, ss.59-65, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.1590/s0102-86502014000100009
- Dergi Adı: Acta Cirurgica Brasileira
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.59-65
- Anahtar Kelimeler: Calcium Phosphates, Bone Regeneration, Tibia, Blood Platelets, Swine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects. Methods: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically. Results: Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone. Conclusion: The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.