Authors’ reply: the biologic importance of the vitamin D binding protein polymorphism in pediatric COVID-19 patients
European Journal of Pediatrics, cilt.180, sa.8, ss.2709-2710, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Kısa Makale
- Cilt numarası: 180 Sayı: 8
- Basım Tarihi: 2021
- Doi Numarası: 10.1007/s00431-021-04109-9
- Dergi Adı: European Journal of Pediatrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.2709-2710
- Anahtar Kelimeler: COVID-19, Vitamin D, Vitamin D binding protein
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
What is Known?• Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection• Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolitesWhat is New?• Lower 25 OH vitamin D levels were associated with higher inflammation markers, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response• Further studies are warranted to investigate the possible causal association of DBP levels and polymorphism with vitamin D status (total and bioavailable vitamin D) in COVID-19 patients.