Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter
World Journal of Gastroenterology, cilt.14, sa.29, ss.4667-4671, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 29
- Basım Tarihi: 2008
- Doi Numarası: 10.3748/wjg.14.4667
- Dergi Adı: World Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4667-4671
- Anahtar Kelimeler: internal anal sphincter, nitrate tolerance
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim: To investigate the tolerance development against he relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle. Methods: Relaxation responses of ISDN, and electrical field stimulation (EFS) were obtained before and after tolerance induction by ISDN incubation. Results: ISDN (10-7-10-4 mol/L) and SNP (10-8-10-4 mol/L) caused a concentration-dependent relaxation on the basal tonus of the isolated rabbit IAS strips. After a period of 2 h incubation of the 6 × 10-4 mol/L ISDN the relaxation effects of ISDN and SNP did not change compared to control strips. EFS evoked frequency-dependent relaxation in internal anal sphincter smooth muscle and Emax obtained from control strips were not changed in ISDN tolerance-inducing condition. In this study nitrate tolerance was not observed in rabbit IAS smooth muscle. Conclusion: This result shows that nitric oxide donating drugs relaxes the internal anal sphincter of the rabbits without the development of tolerance. © 2008 The WJG Press. All rights reserved.